We are facing major health challenges. In fact, health occupies one of the leading concerns among French people. Issues ranging from a shortage of general practitioners to the ageing population, overcrowded emergency rooms, and the explosion of chronic illnesses have made the situation increasingly unsustainable in terms of the quality, accessibility and costs of healthcare. In light of the evolving healthcare system, especially given the latest government reforms (“My Health 2022”), the challenge is to design a space, services and care that focuses on global proactive prevention, that is able to anticipate the appearance of chronic diseases and that provides support to all populations so they may reach their objectives for living and raging well. Built in Lyon, in the heart of Eurêka Confluence (an Industrial Demonstrator for the Sustainable City), the NextCare Health & Prevention Space, on the one hand, acts as a demonstrator of future spaces for community medicine and, on the other hand, maintains the health capital on a neighbourhood scale. This open and beautiful living space, dedicated to accessible healthcare and well-being, was designed by Linkcity, real estate subsidiary of Bouygues Construction. It is scheduled to open by the end of 2020. Smart city, smart health—Innovation for greater well-being: now more than ever, this project is part of the “Confluence DNA”. Thanks to the development of a regional health indicator, the actions proposed and implemented by the professionals of this innovative Space will thus serve to benefit public health and the general well-being of residents and employees in the Confluence communities.